When the PBCers Organization began, little was known about this rare disease. There was very little research or awareness, and most patients were not diagnosed until the later stages of disease. Since then, much has changed, more research & better awareness leading to earlier diagnosis is helping patients receive treatment sooner. For the majority of PBC patients this is great news. BUT there are patients that do not adequately respond or are unable to tolerate to the current treatments and are still progressing to transplant.
We continue to work with researchers, but our fight is not over until we find the cause and cure for PBC. It is critical to gain more knowledge of the disease and find treatment options. Research cannot move forward without the help of PBC patients participating in the patient registry and clinical trials.
Below is a list of clinical trials for PBC where you can learn more about the individual research efforts. Please help!
Clinical Trials for PBC (2023)
SPONSOR | NIH NUMBER² | STUDY NAME¹ | MEDICATION | INDICATION | STATUS |
Calliditas | Setanaxib | Add on or alternative therapy to UDCA | Recruiting | ||
COUR | CNP-104 | Add on or alternative therapy to UDCA | Recruiting | ||
CymaBay | Seladelpar | Add on or alternative therapy to UDCA | Active, not recruiting | ||
Escient | EP547 | Pruritis (itching) | Recruiting | ||
Genfit | Elative | Elafibranor | Add-on therapy | Active, not recruiting | |
GSK | Linerixibat | Pruritis (itching) | Recruiting | ||
Intercept | OCA & Bezofibrate | Add-on therapy | Recruiting | ||
Mirum | Volixibat | Pruritis (itching) | Recruiting | ||
UNMC | Sulfation of Bile Acids | Sulfation of Bile Acids | Possible biomarker of progression | Active, not recruiting | |
Yale University | Mindfulness in PBC | Add-on therapy | Recruiting | ||
Zydus | Sarolgitazar Magnesium | Alternative therapy to UDCA | Recruiting |
¹ Study name is a link that is sponsor supplied information.
² NIH Number is a link from www.clinicaltrials.gov
NOTE: PBCers Organization does not endorse or promote any specific clinical trial or potential treatment. This information is supplied for your use to educate yourself on potential clinical trials you may qualify for and be interested in participating in. Always discuss any potential enrollment in a clinical trial with your liver specialist as each PBC patient is different and has their own medical situation which must be considered.
The above list is information provided by the research sponsors. PBCers has no input into the content provided and accepts no liability for participation in any clinical trial, whether on this list or not.
Antidote Match allows you to quickly and easily search open, recruiting trials listed in ClinicalTrials.gov. Answer a few questions to find your potential trial matches. Ready to get started?
By selecting “START” above, you will be leaving the PBCers Organization website and accessing your search results on Antidote’s website. The PBCers Organization does not endorse and is not affiliated with any of these clinical trials or medical facilities. We offer Antidote for patient information and ease of access only..
Dr Gershwin’s PBC Research Update
There are a number of ongoing studies in the USA for people with Primary Biliary Cholangitis (PBC) that have failed on UDCA and have an Alkaline Phosphatase greater than 1.5 above normal. If you are interested in learning more about these studies, please email Dr. Eric Gershwin at megershwin@gmail.com Some sponsors will pay travel costs to one of the centers in the US that are running these trials.